Pitchfork is useful to save you ammo, and is very useful verse the Axe Zombies. Cultist just fire at you and laugh. If you want to use this on Rats you'll need to crouch down to effectively hit them.

Flare Gun  is just that. It shoots out signaling flares. When you shoot at an enemy it will lodge into there flesh and stick there. They will glow for a bit before erupting into flames. Sometimes you may need a second shot if the flare burns to quickly. On larger enemies you'll have to pump three or four into them to get them to erupt into flames. Unfortunately flares go out in water, unlike a real flare that would keep on burning. The alternate fire launches a burst of flares that break apart on contact producing a bunch of fires in a large area. When combined with the Guns Akimbo power up you can fire fairly rapidly.
Ammo: Flares

Sawed-Off Double Barrel Shotgun  tends to be general equipment in any good FPS. Its perfect for close and tight areas. It fires a single shot, two shots max before reloading. The alter ternate fire shoots both barrels at once. This thing throws your enemy back in most cases. Its highly effective with the Guns Akimbo power up.
Ammo: Shotgun shells

Thompson's Machine Gun  or Tommy Gun for short is a high speed shooter with great accuracy. A good stream of bullets can hold the enemy at a distance. The alternate fire is produces a sweeping attack from left to right. It allows you to shoot at wider angles quickly with more rounds. Its not all that effective.  Manually covering a wider area seems to prove a better choice. Cool effect nether the less. Guns Akimbo makes this gun and isn't killer.
Ammo: Bullet drums 

Dynamite Bundles  is a bundle of six sticks. You have have two firing modes. One you hold down the button, the longer you hold the button down the farther you can throw it. It appears to explode on contact with an enemy. You'll see a effort meter lights up when you hold the button down, watch for it on the status bar. Just don't hold it to long or the wick will burn out and the dynamite explodes in your face. The alternate mode will toss the dynamite with the wick intact, it will burn a few seconds before erupting.
Ammo: Dynamite bundle

Remote Detonators  are dynamite bundles without a wick. Instead they have a radio detonator strapped to the larger eight stick bundle and you hold the Remote. The dynamite won't detonate on impact so tossing it around is an option.  The alternate fire mode will drop a  bundle on the floor, right below you. You can keep using the alternate mode to drop additional bundles until your satisfied you have enough explosive built up. You can then move away and Remotely detonate the entire stack. Another option is to drop a Proximity Detonator in the pile and leave it for a trap.
Ammo: Remote detonator

Proximity Detonators  are dynamite bundles without a wick. Instead they have a proximity detonator strapped to the six stick bundle. The first firing mode is the same as the standard Dynamite Bundle, you toss it where you want. The alternate firing mode drops them on the ground right below you. Move away quick 'cause they arm soon after contact.
Ammo: Proximity detonator

Napalm Incinerator  This weapon dispatches a big ball of burning napalm. Upon contact it produces an explosion and sets your enemy in flames. The alternate firing mode dispatches several burning napalm balls all in one shot. Guns Akimbo are supported for this weapon.
Ammo: Gasoline cans

Voodoo Doll  The doll is like a pin couching, you repeatedly stab the doll to cause injury to your enemy. They have to be near you and in line of site. If they are not and you stick the doll, you will take damage instead. The damage isn't all that great but its fun to hear them moan each time you stick the doll. The alternate fire uses up 20 points of ammo per use but the effect and damage is great. Unfortunately or fortunate the developers changed the ammo use for alternate fire from 20 points to the entire ammo capacity of the doll in the Plasma Pak.
Ammo: Voodoo doll

Aerosol Can  and a Zippo Lighter produce a portable flamethrower. Its a short range weapon but it does set aflame your enemies if need be. It works great on small creatures like rats and spiders. It may take some time to light up larger enemies. An alternate mode allows you to set the can on fire and toss it for a grenade effect. The alternate firing mode simple drops a lit can at your feet, a few seconds later it will explode.
Ammo: Aerosol Can

Tesla Cannon  emanates a controlled electrical charge to zap your enemies. You'll see there skeletons flash when you zap them. The alternate fire mode will make the gun build up high pre-amp charge, within a few seconds the charge is dispensed into a huge electrical blast. The Guns Akimbo power up also works with this weapon.
Ammo: Batteries

Life Leech This is a handy weapon and tool. The weapon portion of the Life Leech produces rapidly firing fire balls. Supplied by the health of your enemies. If your supply of ammo runs out it will use your health as ammo, so watch how much you use. The alternate fire mode allows you to place the Leech down "on" the ground. It will fire in any direction where the enemy is. In this mode it won't draw health from you, it will just run out of ammo. As a tool the Leech can be used as a step to get up to higher locations. Place it on the ground and you instantly have a boost in height available to you.
Ammo: Trapped Souls

These items are what you carry on yourself for use later.

Crystal Ball In multiplayer mode you can use this item to see your enemies where ever they maybe. Use the "C" key to activate the Ball. While activated hitting the the "C"   or Enter Keys will cycle through all the players. To stop using the Ball simply cycle through the last player and it will turn off.

Doctors Bag When you pick this item up it sits in your inventory until you want to use it. Using the "M" Key will use the bag. It will restore up to 100 points of  health given enough percentage exists. Any unused portions of the Bag will remain until you need it again. Its best to use this bag as a last resort to restore your health. rely on other items and only use the bag if you have to. If you find another Doctors Bag, insure you deplete the one you already have or it will go to waste upon picking up the new bag.

Diving Suit supplies water and depth protection. It will remain in your inventory until you dive underwater, then it automatically activates, the air supply doesn't last very long so know where your going quickly.

Beast Vision These allow you to see enemies in the dark or near dark situations. It highlights them. use the "B" key to activate it.

Jump Boots allow you to jump higher than normal, enough where you can jump on ledges or jump over large pits. Use the "J" key to activate it.

Power Ups

These items are used and activated as soon as you pick them up.

Basic Armor  50 points of armor. It will also increase other armor strength by 50.

Body Armor  100 points of body armor.

Spirit Armor  100 points of spiritual armor, This will protect you from the Voodoo Doll and Life Leech.

Fire Armor  100 points of fire armor. This will protect you from and fire damage.

Super Armor  200 points of  super armor. This armor protects you from the same elements as the Body Armor, Spirit Armor and Fire Armor.

Cloak of Invisibility This cloak will turn you invisible, when you attack you become partially visible. long enough for your enemy to get a fix on you.

Shadow Cloak Apparently this was an unfinished item that the developers never got to.

Reflective Shots do just that Reflects projectiles and axes off of you and into the enemy. Fires, Explosives and Tesla Cannons still will damage you.

Death Mask Makes you invulnerable to any kind of attack. You will not receive any damage. This is only temporally and it will end without any warning. Apparently the developers forgot to create a viewable mask or palette shift of the screen in order to tell you when the Mask is active.

Life Essence  These 'hearts' sometime are left behind from dead enemies. They increase your health by 20 points and max out at 100.

Medicine Pouch  This was seen in the Alpha Blood Pack (a unofficial release of an early version of Blood) They are used in user levels and they increase your health by 50 points with a maximum of 100

Life Seed  A full restore of your health. Gives you 100 points up to a max of 200

Guns Akimbo instantly produces a second weapon in your opposite hand. So you will have double the fire power and rate of fire. Not all weapons will do this. Watch your ammo amount since it will decrease at double the rate.

Shrooms Is a poison that when picked up and eaten it will give you a similar effect as being bitten by a Red spider. The designers planned to have other types of shrooms such as shrink, rage and grow effects. They never made it in the final release. Only this delirium shroom did. An invisible delirium shroom can be found in the men's room of the Monolith Building II Blood Bath level that is available with the Plasma Pak.

Bats can cause damage but its unlikely. If you block there way around they will attack. Just duck if your in a tight area.

Rats do cause allot of damage so try to avoid them. They can't climb small ledges or steps so your safe above them.

Spiders There's more spiders than pictured here, there about the size of a small dog and they come in different colors, red and green. When they bite they cause damage and they may poison at the same time. One poison makes you all wobbly and your view gets distorted. The other poison lowers the detail view only.

Bone Eels these ROT fish can chew you up pretty good. Cleanse the water of these fish before jumping in.

Hell Hands These scary hands move fast and if they get next to you they will make there way to your neck squeezing the life out of you. Your view darkens just as if your underwater and loosing air, you health drops rapidly until they finish the job. You can try to shake them off by tapping your "use" key (usually space) and this tends to be difficult. If you can't get him off then toss some dynamite so you are at least satisfied you took it out.

Lil' Caleb These guys hide in mirrors (plasma pak mirrors only) When a Mirror breaks the pieces turn into little Calebs shooting at you. So try not to break a mirror when your so close to it.

Chrysalid Pods These green pods spit at you and if you get near them you'll take damage. Don't stand in one place to long or there aim will become deadly.

Fire Pods These red pods spit lava at you and if you get near them you'll take damage. Don't stand in one place to long or there aim will become deadly.

Civilians These peoples are usually used by the cultist to give them cover, to hide behind. So you have a choice free the people, or cut them down. Remember Caleb is there to wreak havoc on the Cult and not to be evil against all man.

Mimes the mimes are not really an enemy, there harmless in fact and useful. They let you jump on top of them if you need a boost over a wall. Calebs evil allows the player to choose if one should be eradicated.

Axe Zombies Those axes they use can land a pretty good blow. Most of the time these guys move slow, other times they haul ass and if there's a bunch of them they form a wall, dynamite is no good here since they get close quickly. You'll also find them sneaking up on you if you happen to miss one back in the last battle.

Butcher Zombies Don't get caught in tight areas with these guys. They spit puke at you and throw there butcher knife this creates a frame effect found in other Duke3D and Shadow Warrior. You'll find out they move slow and never throw there knifes upward or downwards.

Cultists Cultists use Shotguns as there weapon. Damage at a distance is minor. You tend to run into allot of these guys.. if they wanna do some damage they will toss some dynamite at you.

Fanatics  Fanatics us Tommy Guns as there primary weapon. Damage at a distance is major.

Zealots Zealots, the Elite cultist use a Tesla Cannon to take you out. Don't try the same thing on them 'cause there robe doubles as electrical armor.

Ackolyte   Although these guys carry a Tommy gun you won't find them using it as they love to toss a bunch of dynamite at you.

  Gargoyles The flying patterns in large areas are usually circles and dive at you. Other times they make a very low pass straight at you. You get a couple together and you'll be looking up alto. They attack using their claws if your far away they will throwing bones at you.

Hell Hounds These weird dog-like creatures have lost their skin (poor little creatures), and possessed the ability of breathing fire. Almost as the only creatures that really can kill you, they try to burn you, and mostly they do. These annoying creatures are usually behind corners, just hit few bundles of dynamites into corners and they'll probably be dead.

Gill Beasts These slow, noisily fish-like creatures are not threat on ground, but in water... Tommy gun/Tesla Cannon/Napalm Launcher

Phantasms More annoying enemies, eh? Well these can be real threat, like you can't kill them when they are invisible, and they become visible when you are at the range of their scythe. And the annoying part, they sometimes really can scare you when they strike from cabinets with their rampaging shout. Killed most easiest with the Tommy gun. Or if they come nearby, just shoot two Shotgun's alternative fires...

Stone Gargoyles are the same as standard Gargoyles except there a bit more aggressive and they usually come alive from stone sculptures. They don't do this all the time , but enough that you'll watch your back when passing a statue.

Cheogh This guy is one of the Bosses. He is much larger than the other Gargoyles. He shoots packets of light from his eyes and when he's up close he claws you. You can hear his wings flapping and most of the time he moves pretty quick.

Shial Is the largest of all spiders and she is one of the Bosses. She normally dispatches a bunch of the smaller dog size spiders on you. A dozen or more at a time. She'll bite you if she gets a chance.

Cerberos This creature is one of the Bosses. Its four times the size of a Hell Hound and it shoots hot napalm at you. They can dispense the napalm fairly quickly. Despite there use of Napalm, they are not immune to it.

Tchernobog Using Napalm Launcher or Tesla Cannon is the best way to kill this false prophet.

Priest is like the Fanatics but much more aggressive, There in red robes. You'll find out quickly that they are tougher than Fanatics but do use a Tommy Gun. Upon there "destruction" they mutate into the Beast below.

Beast are the result of a Priest being defeated. They are mutations who use a killer stomp attack and when near they use there fists. You can avoid an attack by moving far enough away or get out of line of site. Don't bother jumping off the ground as there stomp is more than a ground rumbling attack, its evil.

Ironically the developers originally wanted the Beast to be a mutation for the player character Cabel. It never made it into the release and was salvage for use in the plasma pak.

Episode 1: THE WAY OF ALL FLESH

"Cradle to Grave" .... James Wilson
"Wrong Side of the Tracks" .... Craig Hubbard
"Phantom Express" .... James Wilson
"Dark Carnival" .... Kevin Kilstrom, James Wilson
"Hallowed Grounds" .... Nick Newhard, Craig Hubbard, Terry Hamel
"The Great Temple" .... Terry Hamel, James Wilson
"Altar of Stone" .... James Wilson
"House of Horror" .... James Wilson

Episode 2: EVEN DEATH MAY DIE

"Shipwrecked" .... Craig Hubbard
"The Lumber Mill" .... Craig Hubbard
"Rest for the Wicked" .... Kevin Kilstrom & Craig Hubbard
"The Overlooked Hotel" .... Kevin Kilstrom & Craig Hubbard
"The Haunting" .... James Wilson & Kevin Kilstrom
"The Cold Rush" .... James Wilson
"Bowels of the Earth" .... James Wilson
"The Lair of Shial" .... James Wilson
"Thin Ice" .... James Wilson

Episode 3: FAREWELL TO ARMS

"Ghost Town" .... James Wilson
"The Siege" .... Craig Hubbard
"Raw Sewage" .... James Wilson
"The Sick Ward" .... Craig Hubbard
"Spare Parts" .... James Wilson & Craig Hubbard
"Monster Bait" .... James Wilson & Terry Hamel
"The Hall of Cerberus" .... Craig Hubbard
"In the Dog House" .... James Wilson

Episode 4: DEAD RECKONING

"Butchery Loves Company" .... James Wilson
"Breeding Grounds" .... James Wilson
"Sacrificial Orifice" .... James Wilson
"Charnel Bog" .... Kevin Kilstrom
"Fire and Brimstone" .... James Wilson
"The Ganglion Depths" .... James Wilson & Terry Hamel
"A Separate Piece" .... Craig Hubbard & Nick Newhard
"The Hall of the Epiphany" .... Kevin Kilstrom
"Mall of the Dead" .... James Wilson & Craig Hubbard